Benzo[b]thiophene-2-carboxamide, N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-
ANA-12
CAS: 219766-25-3
Molecular Formula: C22H21N3O3S
Benzo[b]thiophene-2-carboxamide, N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]- - Names and Identifiers
Benzo[b]thiophene-2-carboxamide, N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]- - Physico-chemical Properties
| Molecular Formula | C22H21N3O3S |
| Molar Mass | 407.49 |
| Solubility | 10 mM in DMSO |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| In vitro study | ANA-12 can selectively bind directly to the TrkB receptor and inhibit the TrkB downstream pathway without changing the function of TrkA and TrkC. In nnr5 PC12-TrkB cells, 10 nM of ANA-12 prevented brain-derived neurotrophic factor (BDNF)-mediated neurite outgrowth. In DRG neurons, ANA-12 abolished the effect of BDNF to increase inward currents. |
| In vivo study | In adult C57BL6/129svev F1s mice, ANA-12 (0.5 mg/kg, I. P.) reduced brain TrkB activity and ameliorated anxiety-and depression-related behaviors without affecting neuronal survival. ANA-12 (0.5 mg/kg, I. P.) showed an antidepressant effect on lipopolysaccharide-induced depressive behavior in male C57BL/6 mice. In male Sprague-Dawley rats, ANA-12 (3 μg/Dose) blocked the feeding-reducing effect of the medial subnucleus of the solitary tract (mNTS) BDNF. ANA-12 reversed alcohol intake and down-regulated D3 receptor expression in male wild-type mice, but was ineffective in D3R-/-type mice. In male CocSired rats, intraperitoneal injection of ANA-12(0.5 mg/kg) reversed the attenuation of cocaine self-administration. |
Benzo[b]thiophene-2-carboxamide, N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]- - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
Benzo[b]thiophene-2-carboxamide, N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.454 ml | 12.27 ml | 24.541 ml |
| 5 mM | 0.491 ml | 2.454 ml | 4.908 ml |
| 10 mM | 0.245 ml | 1.227 ml | 2.454 ml |
| 5 mM | 0.049 ml | 0.245 ml | 0.491 ml |
Last Update：2024-01-02 23:10:35
Benzo[b]thiophene-2-carboxamide, N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]- - Reference Information
| biological activity | ANA-12 is a selective TrkB antagonist, the Kd for the high and low affinity sites were 10 nM and 12 μm, respectively. |
Last Update：2024-04-09 21:01:54
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Spot supply
Product Name: ANA-12 Visit Supplier Webpage Request for quotationCAS: 219766-25-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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